PhD Candidate in Functional Genomics and Pancreatic Cancer Research; part time 65% (m/w/d) (Forschungsreferent/in)

Scope of duties

• Work on the project “Global mapping of drug synergy landscapes using massively parallel Cas13d genetic interaction screening” within the German Cancer Aid-funded DEFEAT-PDAC consortium ·
• Investigate therapeutically relevant genetic dependencies and drug combinations in pancreatic ductal adenocarcinoma ·
• Perform and analyze high-throughput genetic interaction screens, particularly using Cas13d-based screening approaches ·
• Plan and conduct molecular and cell biological experiments to validate identified targets and drug synergies ·
• Investigate rational combination therapies, including combinations with RAS/KRAS inhibitors
• · Work with pancreatic cancer cell lines and additional preclinical model systems
• · Apply modern methods in cell biology, molecular biology, functional genomics and proteomics
• · Quantitatively analyze, interpret and document experimental data
• · Collaborate closely with research groups and technology platforms within the DEFEAT-PDAC network
• · Present research findings at project meetings and scientific conferences and contribute to scientific publications

Our requirements

• A successfully completed university degree, preferably a Master’s degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology or a related life-science discipline ·
• Strong interest in cancer biology, functional genomics, mechanisms of therapy resistance and translational cancer research ·
• Practical experience in cell and molecular biology, for example mammalian cell culture, transfection, RNA and protein analysis, immunoblotting or microscopy ·
• Previous experience with CRISPR-based technologies, genetic screens, proteomics, next-generation sequencing or bioinformatic data analysis is an advantage, but not mandatory ·
• Motivation to learn new experimental technologies and quantitative analysis methods
• · A careful, structured and independent approach to scientific work
• · Scientific curiosity, high motivation and enthusiasm for experimental research
• · Strong communication and teamwork skills and an interest in working in an interdisciplinary and international research environment
• · Very good written and spoken English
• · German language skills are not required

Our offer

• An innovative and challenging PhD project within the DEFEAT-PDAC consortium, a national and internationally connected research network funded by German Cancer Aid ·
• An international and interdisciplinary research environment at the interface of cancer biology, functional genomics, proteomics and clinical translation ·
• State-of-the-art laboratories and access to advanced screening, proteomics, sequencing and data-analysis platforms ·
• Close collaboration with basic scientists, bioinformaticians and clinician scientists ·
• Structured scientific supervision and support for your professional and personal development
• · Opportunities to participate in national and international conferences, workshops and training programmes
• · A collaborative, supportive and inspiring working environment that encourages scientific independence and the development of your own ideas
• · Employment according to the German public-sector collective agreement, including annual leave and additional benefits in accordance with the applicable regulations
• ·

The position is initially funded for three years. Subject to a positive scientific re-evaluation, an extension for up to two additional years is possible · The position is based at the LMU University Hospital, Campus Großhadern, in Munich · The remuneration is based on the Collective Agreement for the Public Service of the Federal States (TV-Ärzte) including all allowances customary in the public service.